GnRH Receptor
Gonadotropin releasing hormone receptor; GNRHR
The GnRH receptor (Gonadotropin-releasing hormone receptor, GNRHR) is a member of the rhodopsin-like G protein-coupled receptor (GPCR) family and consists of seven transmembrane helical domains connected via extra- and intra-cellular segments. GnRH receptor is located on the plasma membrane of gonadotrophs, pituitary cells that synthesize the gonadotrophins LH and FSH.
Mammalian type I and II GnRH receptors show differential ligand preference for GnRH-I (also named as LHRHR) and GnRH-II, respectively. All GnRH receptors activate the Gq/11 family of G proteins, which activate phospholipase C-catalyzed production of second messengers that activate protein kinase C (PKC). GnRH receptor activated by GnRH analogues stimulates the synthesis and release of LH and FSH. GnRH receptors can be used for the research of breast and prostate cancer, regulation of fertility, endometriosis and a range of other medical and veterinary uses.
All Product Categories
-
GnRH Receptor Related Products (161)
Related Products (161)
-
Antibodies (3)
-
(Des-Gly10,Des-Ser4,D-Leu6,Pro-NHEt9)-LHRH
0 ImagesCat. No.: HY-P4440CAS No.: 267878-61-5(Des-Gly10,Des-Ser4,D-Leu6,Pro-NHEt9)-LHRH is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development.
-
5α-Pregnane-3α,20α-diol
0 ImagesCat. No.: HY-107850ACAS No.: 566-58-5Synonyms: Allopregnanediol5α-Pregnane-3α,20α-diol (Allopregnanediol) is a derivative of progesterone and is one of the various steroids secreted by the ovaries of rats. 5α-Pregnane-3α,20α-diol can significantly stimulate the release of luteinizing hormone (LH) in castrated rats that have been pre-treated with estrogen, while simultaneously inhibiting the secretion of follicle-stimulating hormone (FSH).
-
(Des-Gly10,D-Leu6,Orn8,Pro-NHEt9)-LHRH
0 ImagesCat. No.: HY-P4445CAS No.: 1051970-61-6(Des-Gly10,D-Leu6,Orn8,Pro-NHEt9)-LHRH is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development.
-
RS-18286
0 ImagesCat. No.: HY-P2110CAS No.: 109458-76-6RS-18286 is a potent luteinizing-hormone (LH)-releasing hormone (LHRH) antagonist. RS-18286 blocks the pituitary LHRH receptor and suppresses pituitary luteinizing-hormone (LH) secretion and reduce serum concentrations of gonadal steroids.
-
(D-Leu6,Pro-NHEt9)-LHRH (4-9)
0 ImagesCat. No.: HY-P4538CAS No.: 202333-85-5(D-Leu6,Pro-NHEt9)-LHRH (4-9) is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development.
-
Elagolix sodium (Standard)
0 ImagesSynonyms: NBI-56418 sodium (Standard)Elagolix sodium (Standard) is the analytical standard of Elagolix sodium. This product is intended for research and analytical applications. Elagolix sodium is a human GnRH receptor (GnRHR) antagonist with an IC50 and Ki of 0.25 and 3.7 nM, respectively.
-
Alarelin Acetate (Standard)
0 ImagesCat. No.: HY-17405RCAS No.: 79561-22-1Synonyms: Alarelin (Standard)Alarelin (Acetate) (Standard) is the analytical standard of Alarelin (Acetate). This product is intended for research and analytical applications. Alarelin acetate is a synthetic GnRH agonist.
-
Cetrorelix-d10
0 ImagesCat. No.: HY-P0009S1Synonyms: SB-75-d10Cetrorelix-d10 (SB-75-d10) is the d10-labeled Cetrorelix (HY-P0009). Cetrorelix is a competitive gonadotropin-releasing hormone receptor (GnRHR) antagonist with a Kd of 0.19 nM. Cetrorelix inhibits the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), thereby suppressing the secretion of downstream sex steroids. Cetrorelix prevents ovulation, induces reversible reproductive shutdown and azoospermia, reduces ovarian fibrosis, improves superovulation outcomes, and inhibits chemotherapy-induced mitochondria-dependent apoptosis. Cetrorelix is applicable for fertility assistance research.
-
SKI2496
0 ImagesCat. No.: HY-117982CAS No.: 1308378-95-1SKI2496 is an orally active GnRH receptor antagonist (IC50: 0.25 nM for hGnRHR, 13.2 nM for monkey GnRHR, 279.2 nM for rat GnRHR). SKI2496 blocks Ca2+ flux with an IC50 value of 0.76 nM. SKI2496 inhibits ERK1/2 phosphorylation with an IC50 value of 2.6 nM. SKI2496 inhbits serum LH concentrations, and can be used for research of sex hormone-dependent disorders.
-
Relugolix (Standard)
0 ImagesSynonyms: TAK-385 (Standard)Relugolix (Standard) is the analytical standard of Relugolix. This product is intended for research and analytical applications. Relugolix (TAK-385) is a potent, orally active, nonpeptidic gonadotropin-releasing hormone (GnRH) antagonist. Relugolix possesses high affinity and potent antagonistic activity for human receptor (binding IC50=0.33 nM) and monkey receptor (IC50=0.32 nM) compared with TAK-013 (HY-100209). Relugolix is used for the study of sex-hormone-dependent diseases, such as including endometriosis, uterine fibroids and prostate cancer et al.
-
Lutrelin
0 ImagesCat. No.: HY-106043CAS No.: 66866-63-5Synonyms: Wy 40972Lutrelin (Wy 40972) is a luteinizing hormone releasing hormone (LHRH) agonist. Lutrelin inhibits the growth of the endometrial expiant in rats.
-
Dimethandrolone undecanoate
0 ImagesCat. No.: HY-164032CAS No.: 366472-45-9Synonyms: 7α,11β-Dimethyl-17β-hydroxyestr-4-en-3-one 17-undecanoateDimethandrolone undecanoate (7α,11β-Dimethyl-17β-hydroxyestr-4-en-3-one 17-undecanoate) exhibits withrogens and progesterone activity. Dimethandrolone undecanoate inhibits production of gonadotropins, suppresses testosterone production, and thus inhibits sperm production. Dimethandrolone undecanoate is potent for development of male hormone contraceptives.
-
(R)-Elagolix (Standard)
0 ImagesCat. No.: HY-14789RCAS No.: 834153-87-6Synonyms: NBI-56418 (Standard)(R)-Elagolix (Standard) is the analytical standard of (R)-Elagolix. This product is intended for research and analytical applications. Elagolix is a highly effective, selective, oral-active, short-term, non-peptide gonadotropin-releasing hormone receptor (GnRH receptor) antagonist (KD = 54 pM) and NFAT inhibitor, which can be used to study pain related to endometriosis. .
-
A-76154
0 ImagesCat. No.: HY-125701CAS No.: 136989-30-5A-76154, an octapeptide, is a potent reduced-size luteinizing hormone-releasing hormone (LHRH) antagonist.
-
MI-1544
0 ImagesCat. No.: HY-P2357CAS No.: 87565-51-3MI-1544 is a powerful GnRH antagonist. MI-1544 induces inhibitory effects on the pituitary LH release and on gonads. MI-1544 can be used for the research of antifertility effect.
-
BIM 21009
0 ImagesCat. No.: HY-P2028CAS No.: 106881-54-3
-
Lutropin alfa (FLAG, His Tag)
0 ImagesCat. No.: HY-P992149CAS No.: 152923-57-4Lutropin alfa (FLAG, His Tag) is a recombinant human luteinizing hormone (LH). Lutropin alfa (FLAG, His Tag) consists of non-covalently linked α and β subunits, and its activity is similar to that of natural luteinizing hormone. Lutropin alfa (FLAG, His Tag) is used to stimulate follicular development in infertility.
-
Antide acetate
0 ImagesCat. No.: HY-P0013ACAS No.: 625092-10-6Synonyms: D-21074 acetate; ORF 23541 acetateAntide (D-21074) acetate is a potent LHRH antagonist. Antide also can be used for the research of prostatic cancer.
-
Elagolix-d6 sodium
0 ImagesCat. No.: HY-W751574Synonyms: NBI-56418-d6 sodiumElagolix-d6 (sodium) (NBI-56418-d6 (sodium)) is deuterium labeled Elagolix sodium. Elagolix sodium is a highly effective, selective, oral-active, short-term, non-peptide gonadotropin-releasing hormone receptor (GnRH receptor) antagonist (KD = 54 pM) and NFAT inhibitor, which can be used to study pain related to endometriosis. .
-
T-98475
0 ImagesCat. No.: HY-107533CAS No.: 199119-18-1T-98475 (Compound 26d) is a potent, orally active, non-peptide luteinizing hormone-releasing hormone (LHRH) receptor antagonist with an IC50 of 0.2 nM.
